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Different fonts are corresponding to different character-sets, the same font effects differently for different languages.
You could specify specific fonts for lyrics of different languages using AutoLyric feature, for example, [Arial] font for English lyrics, [Microsoft Sans Serif] font for Chinese lyrics, and so on.
If the lyric matches diffrent languages(codepages), only the front one in the lyric Font list will be chosen, generally, English font should be list prior, because almost all fonts support English. Therefore, if you specify [Arial] font for English lyrics, [Microsoft Sans Serif] font for Chinese lyrics, [Arial] should be listed before [Microsoft Sans Serif].
In the "Select language(codepage)" dialog, "(System Default" means the system default language, "(Automatic)" means that this font will be chosen if no font in the list matches the language of the lyrics.
The setting of the image above, indicates that Engilsh lyrics will apply Arial font automatically, and Simplified-Chinese lyrics will apply [楷体] and display vertically.